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Inhibition of Matrix Metalloproteinase-2 Enhances Radiosensitivity by Abrogating Radiation-induced FoxM1-mediated G2/M Arrest in A549 Lung Cancer Cells
Matrix metalloproteinase-2 (MMP-2) is known to degrade the collagen IV, play a role in radiation-induced lung injury. We therefore investigated the anti-tumor effects of combining MMP-2 inhibition using an adenovirus expressing siRNA against MMP-2 (Ad-MMP-2-Si) with radiation therapy (IR) on A549 lu...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2663016/ https://ncbi.nlm.nih.gov/pubmed/19165865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24209 |
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