p70 Ribosomal S6 Kinase Is Required for Airway Smooth Muscle Cell Size Enlargement but Not Increased Contractile Protein Expression

We examined the contribution of p70 ribosomal S6 kinase (p70S6K) to airway smooth muscle hypertrophy, a structural change found in asthma. In human airway smooth muscle cells, transforming growth factor (TGF)-β, endothelin-1, and cardiotrophin-1 each induced phosphorylation of p70S6K and ribosomal p...

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Main Authors: Deng, Huan, Hershenson, Marc B., Lei, Jing, Bitar, Khalil N., Fingar, Diane C., Solway, Julian, Bentley, J. Kelley
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2010
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891500/
https://ncbi.nlm.nih.gov/pubmed/19648476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2009-0037OC
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