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Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle
Airway smooth muscle (ASM) hypertrophy is a cardinal feature of severe asthma, but the underlying molecular mechanisms remain uncertain. Forced protein kinase B/Akt 1 activation is known to induce myocyte hypertrophy in other muscle types, and, since a number of mediators present in asthmatic airway...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3094029/ https://ncbi.nlm.nih.gov/pubmed/21378028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00119.2009 |
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