Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle

Airway smooth muscle (ASM) hypertrophy is a cardinal feature of severe asthma, but the underlying molecular mechanisms remain uncertain. Forced protein kinase B/Akt 1 activation is known to induce myocyte hypertrophy in other muscle types, and, since a number of mediators present in asthmatic airway...

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Autors principals: Ma, Lan, Brown, Melanie, Kogut, Paul, Serban, Karina, Li, Xiaojing, McConville, John, Chen, Bohao, Bentley, J. Kelley, Hershenson, Marc B., Dulin, Nickolai, Solway, Julian, Camoretti-Mercado, Blanca
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094029/
https://ncbi.nlm.nih.gov/pubmed/21378028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00119.2009
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