Inhibition of Glycogen Synthase Kinase-3β Is Sufficient for Airway Smooth Muscle Hypertrophy

We examined the role of glycogen synthase kinase-3β (GSK-3β) inhibition in airway smooth muscle hypertrophy, a structural change found in patients with severe asthma. LiCl, SB216763, and specific small interfering RNA (siRNA) against GSK-3β, each of which inhibit GSK-3β activity or expression, incre...

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Autori principali: Deng, Huan, Dokshin, Gregoriy A., Lei, Jing, Goldsmith, Adam M., Bitar, Khalil N., Fingar, Diane C., Hershenson, Marc B., Bentley, J. Kelley
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Protein Synthesis, Post-Translational Modification, and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442285/
https://ncbi.nlm.nih.gov/pubmed/18252708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800624200
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