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Deficiency of Bloom syndrome helicase activity is radiomimetic
Bloom syndrome is caused by homozygous mutations in BLM, which encodes a RecQ DNA helicase. Patient-derived cells deficient in BLM helicase activity exhibit genetic instability—apparent cytogenetically as sister chromatid exchanges—and activated DNA damage signaling. In this report, we show that BLM...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891340/ https://ncbi.nlm.nih.gov/pubmed/18787401 |
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