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Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists
The protein-protein interaction of p53 and mdm2 is an important anticancer target. The interface, however, is very hydrophobic and naturally results in very hydrophobic antagonists. We used the Orru three component reaction (O-3CR) along with a rapid and efficient, recently discovered amidation reac...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891308/ https://ncbi.nlm.nih.gov/pubmed/19548636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc9000218 |
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