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DNA polymerase η lacking the ubiquitin-binding domain promotes replicative lesion bypass in humans cells
The Rad6-Rad18 mediated monoubiquitylation of proliferating cell nuclear antigen (PCNA) at lys 164 plays a crucial role in promoting the access of translesion synthesis (TLS) DNA polymerases (Pols) to PCNA in the replication fork stalled at a lesion site. Although a number of genetic and biochemical...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890850/ https://ncbi.nlm.nih.gov/pubmed/20498091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005492107 |
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