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DNA polymerase η lacking the ubiquitin-binding domain promotes replicative lesion bypass in humans cells

The Rad6-Rad18 mediated monoubiquitylation of proliferating cell nuclear antigen (PCNA) at lys 164 plays a crucial role in promoting the access of translesion synthesis (TLS) DNA polymerases (Pols) to PCNA in the replication fork stalled at a lesion site. Although a number of genetic and biochemical...

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Bibliografiske detaljer
Main Authors: Acharya, Narottam, Yoon, Jung-Hoon, Hurwitz, Jerard, Prakash, Louise, Prakash, Satya
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890850/
https://ncbi.nlm.nih.gov/pubmed/20498091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005492107
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