Mixed T cell receptor dimers harbor potentially harmful neoreactivity

Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to target both hematological malignancies and solid tumors. By introducing a TCR, large numbers of T cells with defined antigen (Ag) specificity can be obtained. However, by introduction of a TCR, mixed TCR d...

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Bibliografiska uppgifter
Huvudupphovsmän: van Loenen, Marleen M., de Boer, Renate, Amir, Avital L., Hagedoorn, Renate S., Volbeda, Gerdien L., Willemze, Roelof, van Rood, Johannes J., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890759/
https://ncbi.nlm.nih.gov/pubmed/20534461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005802107
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