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Tissue-specific p19(Arf) regulation dictates the response to oncogenic K-ras
The ability of oncogenes to engage tumor suppressor pathways represents a key regulatory mechanism that can limit the outgrowth of incipient tumor cells. For example, in a number of settings oncogenic Ras strongly activates the Ink4a/Arf locus, resulting in cell cycle arrest or senescence. The capac...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890471/ https://ncbi.nlm.nih.gov/pubmed/20479239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004796107 |
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