PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor–positive breast cancer

PIK3CA mutations are reported to be present in approximately 25% of breast cancer (BC), particularly the estrogen receptor–positive (ER+) and HER2-overexpressing (HER2+) subtypes, making them one of the most common genetic aberrations in BC. In experimental models, these mutations have been shown to...

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Main Authors: Loi, Sherene, Haibe-Kains, Benjamin, Majjaj, Samira, Lallemand, Francoise, Durbecq, Virginie, Larsimont, Denis, Gonzalez-Angulo, Ana M., Pusztai, Lajos, Symmans, W. Fraser, Bardelli, Alberto, Ellis, Paul, Tutt, Andrew N. J., Gillett, Cheryl E., Hennessy, Bryan T., Mills, Gordon B., Phillips, Wayne A., Piccart, Martine J., Speed, Terence P., McArthur, Grant A., Sotiriou, Christos
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890442/
https://ncbi.nlm.nih.gov/pubmed/20479250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907011107
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