The Alternative Medicine Pawpaw and Its Acetogenin Constituents Suppress Tumor Angiogenesis via the HIF-1/VEGF Pathway

Products that contain twig extracts of pawpaw (Asimina triloba, Annonaceae) are widely consumed anticancer alternative medicines. Pawpaw crude extract (CE) and purified acetogenins inhibited hypoxia-inducible factor-1 (HIF-1)-mediated hypoxic signaling pathways in tumor cells. In T47D cells, pawpaw...

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Main Authors: Coothankandaswamy, Veena, Liu, Yang, Mao, Shui-Chun, Morgan, J. Brian, Mahdi, Fakhri, Jekabsons, Mika B., Nagle, Dale G., Zhou, Yu-Dong
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890309/
https://ncbi.nlm.nih.gov/pubmed/20423107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np100228d
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