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mTOR and GSK-3 shape the CD4(+) T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS
Prolonged inhibition of the kinase, mammalian target of rapamycin (mTOR), during myeloid dendritic cell (DC) generation confers resistance to maturation. Recently, however, mTOR inhibition immediately before Toll-like receptor ligation has been found to exert proinflammatory effects on myeloid cells...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890188/ https://ncbi.nlm.nih.gov/pubmed/20335217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-251488 |
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