Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction

Mammalian target of rapamycin (mTOR) is an important, yet poorly understood integrative kinase that regulates immune cell function. mTOR functions in 2 independent complexes: mTOR complex (mTORC) 1 and 2. The immunosuppressant rapamycin (RAPA) inhibits mTORC1 but not mTORC2 and causes a paradoxical...

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Detalhes bibliográficos
Main Authors: Rosborough, Brian R., Raïch-Regué, Dàlia, Matta, Benjamin M., Lee, Keunwook, Gan, Boyi, DePinho, Ronald A., Hackstein, Holger, Boothby, Mark, Turnquist, Hēth R., Thomson, Angus W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643762/
https://ncbi.nlm.nih.gov/pubmed/23444404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-448290
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