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Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin

BACKGROUND: One of the most commonly used classes of anti-cancer drugs presently in clinical practice is the platinum-based drugs, including cisplatin. The efficacy of cisplatin therapy is often limited by the emergence of resistant tumours following treatment. Cisplatin resistance is multi-factoria...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Stubbert, Lawton J, Smith, Jennifer M, McKay, Bruce C
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889890/
https://ncbi.nlm.nih.gov/pubmed/20470425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-207
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