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The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline

Slits and their Roundabout (Robo) receptors mediate repulsive axon guidance at the Drosophila ventral midline and in the vertebrate spinal cord. Slit is cleaved to produce fragments with distinct signaling properties. In a screen for genes involved in Slit-Robo repulsion, we have identified the Adam...

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Bibliografiske detaljer
Main Authors: Coleman, Hope A., Labrador, Juan-Pablo, Chance, Rebecca K., Bashaw, Greg J.
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889607/
https://ncbi.nlm.nih.gov/pubmed/20570941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.047993
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