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The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline

Slits and their Roundabout (Robo) receptors mediate repulsive axon guidance at the Drosophila ventral midline and in the vertebrate spinal cord. Slit is cleaved to produce fragments with distinct signaling properties. In a screen for genes involved in Slit-Robo repulsion, we have identified the Adam...

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Détails bibliographiques
Auteurs principaux: Coleman, Hope A., Labrador, Juan-Pablo, Chance, Rebecca K., Bashaw, Greg J.
Format: Artigo
Langue:Inglês
Publié: Company of Biologists 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889607/
https://ncbi.nlm.nih.gov/pubmed/20570941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.047993
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