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The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline

Slits and their Roundabout (Robo) receptors mediate repulsive axon guidance at the Drosophila ventral midline and in the vertebrate spinal cord. Slit is cleaved to produce fragments with distinct signaling properties. In a screen for genes involved in Slit-Robo repulsion, we have identified the Adam...

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書誌詳細
主要な著者: Coleman, Hope A., Labrador, Juan-Pablo, Chance, Rebecca K., Bashaw, Greg J.
フォーマット: Artigo
言語:Inglês
出版事項: Company of Biologists 2010
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889607/
https://ncbi.nlm.nih.gov/pubmed/20570941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.047993
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