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The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline

Slits and their Roundabout (Robo) receptors mediate repulsive axon guidance at the Drosophila ventral midline and in the vertebrate spinal cord. Slit is cleaved to produce fragments with distinct signaling properties. In a screen for genes involved in Slit-Robo repulsion, we have identified the Adam...

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Bibliografske podrobnosti
Main Authors: Coleman, Hope A., Labrador, Juan-Pablo, Chance, Rebecca K., Bashaw, Greg J.
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889607/
https://ncbi.nlm.nih.gov/pubmed/20570941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.047993
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