Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

Most laboratory mouse strains including C57BL/6J do not produce detectable levels of pineal melatonin owing to deficits in enzymatic activity of arylalkylamine N-acetyltransferase (AANAT) and N-acetylserotonin O-methyl transferase (ASMT), two enzymes necessary for melatonin biosynthesis. Here we rep...

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Détails bibliographiques
Auteurs principaux: Shimomura, Kazuhiro, Lowrey, Phillip L., Vitaterna, Martha Hotz, Buhr, Ethan D., Kumar, Vivek, Hanna, Peter, Omura, Chiaki, Izumo, Mariko, Low, Sharon S., Barrett, R. Keith, LaRue, Silvia I., Green, Carla B., Takahashi, Joseph S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889547/
https://ncbi.nlm.nih.gov/pubmed/20404168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004368107
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