Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

Most laboratory mouse strains including C57BL/6J do not produce detectable levels of pineal melatonin owing to deficits in enzymatic activity of arylalkylamine N-acetyltransferase (AANAT) and N-acetylserotonin O-methyl transferase (ASMT), two enzymes necessary for melatonin biosynthesis. Here we rep...

Full description

Saved in:
Bibliographic Details
Main Authors: Shimomura, Kazuhiro, Lowrey, Phillip L., Vitaterna, Martha Hotz, Buhr, Ethan D., Kumar, Vivek, Hanna, Peter, Omura, Chiaki, Izumo, Mariko, Low, Sharon S., Barrett, R. Keith, LaRue, Silvia I., Green, Carla B., Takahashi, Joseph S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889547/
https://ncbi.nlm.nih.gov/pubmed/20404168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004368107
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items