Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

Most laboratory mouse strains including C57BL/6J do not produce detectable levels of pineal melatonin owing to deficits in enzymatic activity of arylalkylamine N-acetyltransferase (AANAT) and N-acetylserotonin O-methyl transferase (ASMT), two enzymes necessary for melatonin biosynthesis. Here we rep...

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Detalhes bibliográficos
Main Authors: Shimomura, Kazuhiro, Lowrey, Phillip L., Vitaterna, Martha Hotz, Buhr, Ethan D., Kumar, Vivek, Hanna, Peter, Omura, Chiaki, Izumo, Mariko, Low, Sharon S., Barrett, R. Keith, LaRue, Silvia I., Green, Carla B., Takahashi, Joseph S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889547/
https://ncbi.nlm.nih.gov/pubmed/20404168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004368107
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