Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

Most laboratory mouse strains including C57BL/6J do not produce detectable levels of pineal melatonin owing to deficits in enzymatic activity of arylalkylamine N-acetyltransferase (AANAT) and N-acetylserotonin O-methyl transferase (ASMT), two enzymes necessary for melatonin biosynthesis. Here we rep...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Shimomura, Kazuhiro, Lowrey, Phillip L., Vitaterna, Martha Hotz, Buhr, Ethan D., Kumar, Vivek, Hanna, Peter, Omura, Chiaki, Izumo, Mariko, Low, Sharon S., Barrett, R. Keith, LaRue, Silvia I., Green, Carla B., Takahashi, Joseph S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889547/
https://ncbi.nlm.nih.gov/pubmed/20404168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004368107
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge