Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence

The RB protein family (RB, p107, p130) has overlapping and compensatory functions in cell cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has a non-redundant role in tumor suppression. We demonstrate that RB preferentially associates with E2F...

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Huvudupphovsmän: Chicas, Agustin, Wang, Xiaowo, Zhang, Chaolin, McCurrach, Mila, Zhao, Zhen, Mert, Ozlem, Dickins, Ross A., Narita, Masashi, Zhang, Michael, Lowe, Scott W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889489/
https://ncbi.nlm.nih.gov/pubmed/20385362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.01.023
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