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Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2

p53 maintains genome integrity either by regulating the transcription of genes involved in cell cycle, apoptosis, and DNA repair or by interacting with partner proteins. Here we provide evidence for a direct physical interaction between the tumor suppressors p53 and BRCA2. We found that the transact...

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Autors principals: Rajagopalan, Sridharan, Andreeva, Antonina, Rutherford, Trevor J., Fersht, Alan R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889359/
https://ncbi.nlm.nih.gov/pubmed/20421506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003689107
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