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Interaction between the Transactivation Domain of p53 and PC4 Exemplifies Acidic Activation Domains as Single-stranded DNA Mimics

The tumor suppressor p53 regulates cell cycle arrest and apoptosis by transactivating several genes that are critical for these processes. The transcriptional activity of p53 is often regulated by post-translational modifications and its interactions with various transcriptional coactivators. Here w...

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Autors principals: Rajagopalan, Sridharan, Andreeva, Antonina, Teufel, Daniel P., Freund, Stefan M., Fersht, Alan R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755895/
https://ncbi.nlm.nih.gov/pubmed/19525231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006429
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