Interaction between the Transactivation Domain of p53 and PC4 Exemplifies Acidic Activation Domains as Single-stranded DNA Mimics

The tumor suppressor p53 regulates cell cycle arrest and apoptosis by transactivating several genes that are critical for these processes. The transcriptional activity of p53 is often regulated by post-translational modifications and its interactions with various transcriptional coactivators. Here w...

Full description

Saved in:
Bibliographic Details
Main Authors: Rajagopalan, Sridharan, Andreeva, Antonina, Teufel, Daniel P., Freund, Stefan M., Fersht, Alan R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Transcription, Chromatin, and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755895/
https://ncbi.nlm.nih.gov/pubmed/19525231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006429
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items