Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53

Human mitochondrial transcription factor A (TFAM) is a multi-functional protein, involved in different aspects of maintaining mitochondrial genome integrity. In this report, we characterized TFAM and its interaction with tumor suppressor p53 using various biophysical methods. DNA-free TFAM is a ther...

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Detalhes bibliográficos
Main Authors: Wong, Tuck Seng, Rajagopalan, Sridharan, Freund, Stefan M., Rutherford, Trevor J., Andreeva, Antonina, Townsley, Fiona M., Petrovich, Miriana, Fersht, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777442/
https://ncbi.nlm.nih.gov/pubmed/19755502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp750
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