Phenothiazines inhibit S100A4 function by inducing protein oligomerization

S100A4, a member of the S100 family of Ca(2+)-binding proteins, regulates carcinoma cell motility via interactions with myosin-IIA. Numerous studies indicate that S100A4 is not simply a marker for metastatic disease, but rather has a direct role in metastatic progression. These observations suggest...

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Главные авторы: Malashkevich, Vladimir N., Dulyaninova, Natalya G., Ramagopal, Udupi A., Liriano, Melissa A., Varney, Kristen M., Knight, David, Brenowitz, Michael, Weber, David J., Almo, Steven C., Bresnick, Anne R.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889333/
https://ncbi.nlm.nih.gov/pubmed/20421509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913660107
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