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Structure of Ca(2+)-Bound S100A4 and Its Interaction with Peptides Derived from Nonmuscle Myosin-IIA

S100A4, also known as mts1, is a member of the S100 family of Ca(2+)-binding proteins that is directly involved in tumor invasion and metastasis via interactions with specific protein targets, including nonmuscle myosin-IIA (MIIA). Human S100A4 binds two Ca(2+) ions with the typical EF-hand exhibiti...

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Detalhes bibliográficos
Main Authors: Malashkevich, Vladimir N., Varney, Kristen M., Garrett, Sarah C., Wilder, Paul T., Knight, David, Charpentier, Thomas H., Ramagopal, Udupi A., Almo, Steven C., Weber, David J., Bresnick, Anne R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633413/
https://ncbi.nlm.nih.gov/pubmed/18410126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi702537s
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