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Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca(2+)-dependent regulation of polycystin-2 channel activity
The C-terminal cytoplasmic tail of polycystin-2 (PC2/TRPP2), a Ca(2+)-permeable channel, is frequently mutated or truncated in autosomal dominant polycystic kidney disease. We have previously shown that this tail consists of three functional regions: an EF-hand domain (PC2-EF, 720–797), a flexible l...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889120/ https://ncbi.nlm.nih.gov/pubmed/20439752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912295107 |
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