Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Despite abundant evidence that aberrant Rho-family GTPase activation contributes to most steps of cancer initiation and progression, there is a dearth of inhibitors of their effectors (e.g., p21-activated kinases). Through high-throughput screening and structure-based design, we identify PF-3758309,...

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Bibliografski detalji
Glavni autori: Murray, Brion W., Guo, Chuangxing, Piraino, Joseph, Westwick, John K., Zhang, Cathy, Lamerdin, Jane, Dagostino, Eleanor, Knighton, Daniel, Loi, Cho-Ming, Zager, Michael, Kraynov, Eugenia, Popoff, Ian, Christensen, James G., Martinez, Ricardo, Kephart, Susan E., Marakovits, Joseph, Karlicek, Shannon, Bergqvist, Simon, Smeal, Tod
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889050/
https://ncbi.nlm.nih.gov/pubmed/20439741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911863107
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