MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a novel cytokine displaying selective apoptosis-inducing activity in transformed cells without harming normal cells. The present studies focused on clarifying the mechanism(s) by which glutathione S-transferase (GST)-MDA-7 al...

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Bibliographic Details
Main Authors:	Park, Margaret A., Walker, Teneille, Martin, Aditi Pandya, Allegood, Jeremy, Vozhilla, Nicollaq, Emdad, Luni, Sarkar, Devanand, Rahmani, Mohammed, Graf, Martin, Yacoub, Adly, Koumenis, Costas, Spiegel, Sarah, Curiel, David T., Voelkel-Johnson, Christina, Grant, Steven, Fisher, Paul B., Dent, Paul
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2889018/ https://ncbi.nlm.nih.gov/pubmed/19417161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0073
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MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

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