PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Melanoma differentiation associated gene-7(mda-7) encodes IL-24, a cytokine that can selectively trigger apoptosis in transformed cells. Recombinant mda-7 adenovirus (Ad.mda-7) effectively kills glioma cells, offering a novel gene therapy strategy to address deadly brain tumors. In this study, we de...

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Main Authors: Yacoub, Adly, Hamed, Hossein A., Allegood, Jeremy, Mitchell, Clint, Spiegel, Sarah, Lesniak, Maciej S., Ogretmen, Besim, Dash, Rupesh, Sarkar, Devanand, Broaddus, William C., Grant, Steven, Curiel, David T., Fisher, Paul B., Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890071/
https://ncbi.nlm.nih.gov/pubmed/20103619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4043
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