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PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Melanoma differentiation associated gene-7(mda-7) encodes IL-24, a cytokine that can selectively trigger apoptosis in transformed cells. Recombinant mda-7 adenovirus (Ad.mda-7) effectively kills glioma cells, offering a novel gene therapy strategy to address deadly brain tumors. In this study, we de...

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書誌詳細
主要な著者: Yacoub, Adly, Hamed, Hossein A., Allegood, Jeremy, Mitchell, Clint, Spiegel, Sarah, Lesniak, Maciej S., Ogretmen, Besim, Dash, Rupesh, Sarkar, Devanand, Broaddus, William C., Grant, Steven, Curiel, David T., Fisher, Paul B., Dent, Paul
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890071/
https://ncbi.nlm.nih.gov/pubmed/20103619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4043
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