PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Melanoma differentiation associated gene-7(mda-7) encodes IL-24, a cytokine that can selectively trigger apoptosis in transformed cells. Recombinant mda-7 adenovirus (Ad.mda-7) effectively kills glioma cells, offering a novel gene therapy strategy to address deadly brain tumors. In this study, we de...

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Xehetasun bibliografikoak
Egile Nagusiak: Yacoub, Adly, Hamed, Hossein A., Allegood, Jeremy, Mitchell, Clint, Spiegel, Sarah, Lesniak, Maciej S., Ogretmen, Besim, Dash, Rupesh, Sarkar, Devanand, Broaddus, William C., Grant, Steven, Curiel, David T., Fisher, Paul B., Dent, Paul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890071/
https://ncbi.nlm.nih.gov/pubmed/20103619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4043
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