A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels

Agents that generate reactive oxygen species (ROS) are recognized to enhance MDA-7/IL-24 lethality. The present studies focused on clarifying how such agents enhanced MDA-7/IL-24 toxicity in renal cell carcinoma cells (RCCs). Infection of RCCs with a tropism-modified serotype 5/3 adenovirus expressi...

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Detalhes bibliográficos
Main Authors: Park, Margaret A., Hamed, Hossein A., Mitchell, Clint, Cruickshanks, Nichola, Dash, Rupesh, Allegood, Jeremy, Dmitriev, Igor P., Tye, Gary, Ogretmen, Besim, Spiegel, Sarah, Yacoub, Adly, Grant, Steven, Curiel, David T., Fisher, Paul B., Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061366/
https://ncbi.nlm.nih.gov/pubmed/21119025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.069484
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