A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels

Agents that generate reactive oxygen species (ROS) are recognized to enhance MDA-7/IL-24 lethality. The present studies focused on clarifying how such agents enhanced MDA-7/IL-24 toxicity in renal cell carcinoma cells (RCCs). Infection of RCCs with a tropism-modified serotype 5/3 adenovirus expressi...

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Hlavní autoři: Park, Margaret A., Hamed, Hossein A., Mitchell, Clint, Cruickshanks, Nichola, Dash, Rupesh, Allegood, Jeremy, Dmitriev, Igor P., Tye, Gary, Ogretmen, Besim, Spiegel, Sarah, Yacoub, Adly, Grant, Steven, Curiel, David T., Fisher, Paul B., Dent, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061366/
https://ncbi.nlm.nih.gov/pubmed/21119025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.069484
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