Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery

We have determined whether an adenovirus that comprises the tail and shaft domains of a serotype 5 virus and the knob domain of a serotype 3 virus expressing MDA-7/IL-24, Ad.5/3-mda-7, more effectively infects and kills renal carcinoma cells (RCCs) compared to a serotype 5 virus, Ad.5-mda-7. RCCs ar...

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Detalhes bibliográficos
Main Authors: Eulitt, Patrick J, Park, Margaret A, Hamed, Hossein A, Cruikshanks, Nichola, Yang, Chen, Dmitriev, Igor P, Yacoub, Adly, Curiel, David T, Fisher, Paul B, Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047088/
https://ncbi.nlm.nih.gov/pubmed/20948318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.12.13497
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