Safety and immunogenicity of a human and mouse gp100 DNA vaccine in a phase I trial of patients with melanoma

A differentiation antigen commonly expressed on melanoma cells, gp100 is the target of infiltrating T cells. We conducted a phase I randomized cross-over trial of melanoma patients with either xenogeneic (mouse) or human gp100 plasmid DNA injected intramuscularly at three dosages (100, 500 or 1,500 ...

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Main Authors: Yuan, Jianda, Ku, Geoffrey Y., Gallardo, Humilidad F., Orlandi, Francesca, Manukian, Gregor, Rasalan, Teresa S., Xu, Yinyan, Li, Hao, Vyas, Shachi, Mu, Zhenyu, Chapman, Paul B., Krown, Susan E., Panageas, Katherine, Terzulli, Stephanie L., Old, Lloyd J., Houghton, Alan N., Wolchok, Jedd D.
Format: Artigo
Sprog:Inglês
Udgivet: Academy of Cancer Immunology 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888533/
https://ncbi.nlm.nih.gov/pubmed/19496531
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