Oxazolomycin Biosynthesis in Streptomyces albus JA3453 Featuring an “Acyltransferase-less” Type I Polyketide Synthase That Incorporates Two Distinct Extender Units

The oxazolomycins (OZMs) are a growing family of antibiotics produced by several Streptomyces species that show diverse and important antibacterial, antitumor, and anti-human immunodeficiency virus activity. Oxazolomycin A is a peptide-polyketide hybrid compound containing a unique spiro-linked β-la...

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Bibliographische Detailangaben
Hauptverfasser: Zhao, Chunhua, Coughlin, Jane M., Ju, Jianhua, Zhu, Dongqing, Wendt-Pienkowski, Evelyn, Zhou, Xiufen, Wang, Zhijun, Shen, Ben, Deng, Zixin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888422/
https://ncbi.nlm.nih.gov/pubmed/20406823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090092
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