Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning the Oxazolomycin Biosynthetic Gene Cluster from Streptomyces albus JA3453

Oxazolomycin (OZM), a hybrid peptide-polyketide antibiotic, exhibits potent antitumor and antiviral activities. Using degenerate primers to clone genes encoding methoxymalonyl-acyl carrier protein (ACP) biosynthesis as probes, a 135-kb DNA region from Streptomyces albus JA3453 was cloned and found t...

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Detalhes bibliográficos
Main Authors: Zhao, Chunhua, Ju, Jianhua, Christenson, Steven D., Smith, Wyatt C., Song, Danfeng, Zhou, Xiufen, Shen, Ben, Deng, Zixin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482894/
https://ncbi.nlm.nih.gov/pubmed/16707707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00173-06
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