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Mechanism of acyl transfer by the class A serine beta-lactamase of Streptomyces albus G.

Optimization by energy minimization of stable complexes occurring along the pathway of hydrolysis of benzylpenicillin and cephalosporin C by the Streptomyces albus G beta-lactamase has highlighted a proton shuttle that may explain the catalytic mechanism of the beta-lactamases of class A. Five resid...

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Detalhes bibliográficos
Main Authors: Lamotte-Brasseur, J, Dive, G, Dideberg, O, Charlier, P, Frère, J M, Ghuysen, J M
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1151568/
https://ncbi.nlm.nih.gov/pubmed/1930139
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