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Forward Genetic Analysis Reveals Multiple Gating Mechanisms of TRPV4
TRPV4 is a polymodal cation channel gain-of-function (GOF) allele which causes skeletal dysplasia in humans. To better understand its gating, we screened for additional GOF alleles based on their ability to block yeast proliferation. Repeatedly, only a limited number of such growth-blocking mutation...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2888399/ https://ncbi.nlm.nih.gov/pubmed/20424166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113936 |
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