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Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force
Whether animal ion channels functioning as mechanosensors are directly activated by stretch force or indirectly by ligands produced by the stretch is a crucial question. TRPV4, a key molecular model, can be activated by hypotonicity, but the mechanism of activation is unclear. One model has this cha...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930716/ https://ncbi.nlm.nih.gov/pubmed/20605796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.143370 |
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