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Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force

Whether animal ion channels functioning as mechanosensors are directly activated by stretch force or indirectly by ligands produced by the stretch is a crucial question. TRPV4, a key molecular model, can be activated by hypotonicity, but the mechanism of activation is unclear. One model has this cha...

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Библиографические подробности
Главные авторы: Loukin, Stephen, Zhou, Xinliang, Su, Zhenwei, Saimi, Yoshiro, Kung, Ching
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930716/
https://ncbi.nlm.nih.gov/pubmed/20605796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.143370
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