The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

We have previously identified the E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor (LDLR) (Idol) as a post-translational modulator of LDLR levels. Idol is a direct target for regulation by liver X receptors (LXRs), and its expression is responsive to cellular sterol sta...

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Détails bibliographiques
Auteurs principaux: Hong, Cynthia, Duit, Sarah, Jalonen, Pilvi, Out, Ruud, Scheer, Lilith, Sorrentino, Vincenzo, Boyadjian, Rima, Rodenburg, Kees W., Foley, Edan, Korhonen, Laura, Lindholm, Dan, Nimpf, Johannes, van Berkel, Theo J. C., Tontonoz, Peter, Zelcer, Noam
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888382/
https://ncbi.nlm.nih.gov/pubmed/20427281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123729
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