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A Concise, Phosphate-Mediated Approach to the Total Synthesis of (−)-Tetrahydrolipstatin
[Image: see text] An efficient synthesis of (−)-tetrahydrolipstatin (THL) is reported. This method takes advantage of a phosphate tether-mediated, one-pot, sequential RCM/CM/hydrogenation protocol to deliver THL in 8 total steps from a readily prepared (S,S)-triene. The strategy incorporates selecti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2888003/ https://ncbi.nlm.nih.gov/pubmed/20196547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol1002913 |
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