A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain

HIV-1 integrase catalyzes the insertion of the viral genome into chromosomal DNA. We characterized the structural determinants of the 3′-processing reaction specificity—the first reaction of the integration process—at the DNA-binding level. We found that the integrase N-terminal domain, containing a...

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Bibliographic Details
Main Authors: Carayon, Kevin, Leh, Hervé, Henry, Etienne, Simon, Françoise, Mouscadet, Jean-François, Deprez, Eric
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887959/
https://ncbi.nlm.nih.gov/pubmed/20164093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq087
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