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Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer
BACKGROUND: Telomerase is activated in oncogenesis, which confers an immortal phenotype to cancer cells. The AAA + ATPase Reptin is required for telomerase biogenesis by maintaining telomerase RNA (hTER) stability and is aberrantly expressed in certain cancers. Given its role in chromatin remodeling...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2887797/ https://ncbi.nlm.nih.gov/pubmed/20509972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-132 |
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