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Mitogen-Activated Protein Kinase Cascade-Mediated Histone H3 Phosphorylation Is Critical for Telomerase Reverse Transcriptase Expression/Telomerase Activation Induced by Proliferation

Telomerase activity and telomerase reverse transcriptase (hTERT), the key component of the telomerase complex, are tightly proliferation regulated in normal and malignant cells both in vitro and in vivo; however, underlying mechanisms are unclear. In the present study, we identified mitogen-activate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ge, Zheng, Liu, Cheng, Björkholm, Magnus, Gruber, Astrid, Xu, Dawei
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317632/
https://ncbi.nlm.nih.gov/pubmed/16354694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.1.230-237.2006
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