Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer

BACKGROUND: Telomerase is activated in oncogenesis, which confers an immortal phenotype to cancer cells. The AAA + ATPase Reptin is required for telomerase biogenesis by maintaining telomerase RNA (hTER) stability and is aberrantly expressed in certain cancers. Given its role in chromatin remodeling...

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Detalhes bibliográficos
Main Authors: Li, Wenjuan, Zeng, Jiping, Li, Qiao, Zhao, Li, Liu, Tiantian, Björkholm, Magnus, Jia, Jihui, Xu, Dawei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887797/
https://ncbi.nlm.nih.gov/pubmed/20509972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-132
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