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The Neurotoxic Effects of Estrogen on Ischemic Stroke in Older Female Rats Is Associated with Age-Dependent Loss of Insulin-Like Growth Factor-1

Hormone therapy to postmenopausal females increases the risk and severity of ischemic stroke. Our previous work using an animal model of menopause (reproductive senescence) shows that middle cerebral artery occlusion (MCAo) causes a larger cortical–striatal infarct in this older acyclic group compar...

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Autores principales: Selvamani, Amutha, Sohrabji, Farida
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887690/
https://ncbi.nlm.nih.gov/pubmed/20484627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0761-10.2010
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