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Blood Brain Barrier and Neuroinflammation Are Critical Targets of IGF-1-Mediated Neuroprotection in Stroke for Middle-Aged Female Rats

Ischemia-induced cerebral infarction is more severe in older animals as compared to younger animals, and is associated with reduced availability of insulin-like growth factor (IGF)-1. This study determined the effect of post-stroke IGF-1 treatment, and used microRNA profiling to identify mechanisms...

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Autors principals: Bake, Shameena, Selvamani, Amutha, Cherry, Jessica, Sohrabji, Farida
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949985/
https://ncbi.nlm.nih.gov/pubmed/24618563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091427
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