Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice

Prolonged inflammatory response is associated with left ventricular (LV) dysfunction and adverse remodeling following myocardial infarction (MI). IL-10 inhibits inflammation by suppressing HuR-mediated mRNA stabilization of proinflammatory cytokines. Here we report that following MI, IL-10(−/−) mice...

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Hlavní autoři: Krishnamurthy, Prasanna, Lambers, Erin, Verma, Suresh, Thorne, Tina, Qin, Gangjian, Losordo, Douglas W., Kishore, Raj
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2010
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887267/
https://ncbi.nlm.nih.gov/pubmed/20219984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-149815
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